Inventaire d'enquêtes Demostaf

Information sur la citation

Type Revue - Plos One
Titre Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso.
Auteur(s)
Volume 11
Numéro 3
Publication (Jour/Mois/Année) 2016
Numéros de page e0151565-e0151565
URL http://proxyweb.ined.fr/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=270​31231&lang=fr&site=eds-live&scope=site
Résumé
The adoption of Artemisinin based combination therapies (ACT) constitutes a basic strategy for malaria control in sub-Saharan Africa. Moreover, since cases of ACT resistance have been reported in South-East Asia, the need to understand P. falciparum resistance mechanism to ACT has become a global research goal. The selective pressure of ACT and the possibility that some specific Pfcrt and Pfmdr1 alleles are associated with treatment failures was assessed in a clinical trial comparing ASAQ to AL in Nanoro. Dried blood spots collected on Day 0 and on the day of recurrent parasitaemia during the 28-day follow-up were analyzed using the restriction fragments length polymorphism (PCR-RFLP) method to detect single nucleotide polymorphisms (SNPs) in Pfcrt (codon76) and Pfmdr1 (codons 86, 184, 1034, 1042, and 1246) genes. Multivariate analysis of the relationship between the presence of Pfcrt and Pfmdr1 alleles and treatment outcome was performed. AL and ASAQ exerted opposite trends in selecting Pfcrt K76T and Pfmdr1-N86Y alleles, raising the potential beneficial effect of using diverse ACT at the same time as first line treatments to reduce the selective pressure by each treatment regimen. No clear association between the presence of Pfcrt and Pfmdr1 alleles carried at baseline and treatment failure was observed.;

Études utilisées

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Sondo, Paul, Karim Derra, Seydou Diallo Nakanabo, Zekiba Tarnagda, Adama Kazienga, Odile Zampa, Innocent Valéa, Hermann Sorgho, Ellis Owusu-Dabo, Jean-Bosco Ouédraogo, Tinga Robert Guiguemdé, and Halidou Tinto. "Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso.." Plos One 11, no. 3 (2016): e0151565-e0151565.
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