Inventaire d'enquêtes Demostaf

Information sur la citation

Type Revue - Journal of Medical Virology
Titre HIV-2 infections in a rural Senegalese community
Auteur(s)
Volume 38
Numéro 1
Publication (Jour/Mois/Année) 1992
Numéros de page 67-70
Résumé
In a community study in rural Senegal, 22 human immunodeficiency virus type-2 (HIV-2) seropositive cases and 64 matched controls were examined clinically and evaluated immunologically. The presence of clinical signs was highly correlated with HIV-2 seropositivity: 9 anti-HIV-2 positive patients and 5 controls presented with clinical signs (odd ratio [OR] = 8.2, confidence limits [CL] 2-35). The main symptom associated with HIV-2 seropositivity was a chronic cough (OR = 18.5, CL 1.8-899). The presence of diarrhoea was not significant (OR = 3.1, CL 0.3-3.5). The total number of CD8 cells, CD4/CD8 ratio, β2 microglobulin, and IgG level discriminated between seropositive and seronegative individuals (P {\textless} 0.05). When the anti-HIV-2 positives were grouped as 13 healthy and 9 sick people, red blood cells, lymphocytes, T lymphocytes, CD4 cells, and β2 microglobulin differed significantly. Clinical symptoms were associated with immunodepression: 5 of 14 sick people had less than 500 CD4/μl vs. 1 of 72 healthy persons. This study at the community level emphasizes the clinical and immunological impact of HIV-2 infection. Even if it presents with a longer incubation period than HIV-1, this virus is a major threat to public health. © 1992 Wiley-Liss, Inc.

Études utilisées

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Le Guenno, Pison, Enel, Lagarde, and Seck. "HIV-2 infections in a rural Senegalese community." Journal of Medical Virology 38, no. 1 (1992): 67-70.
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